Triggering Receptor Expressed on Myeloid Cells-1 Inhibitor Targeted to Endothelium Decreases Cell Activation
TREM-1 (Triggering Receptor Expressed on Myeloid cells-1) is an immunoreceptor expressed on neutrophils, monocytes/macrophages, and endothelial cells.It amplifies the inflammatory response driven by Toll-Like Receptors (TLR) engagement.The pharmacological inhibition of TREM-1 confers protection in several pre-clinical models of acute inflammation.I